Thermo Scientific Q Exactive UHMR

Thermo Q Exactive UHMR Mass Spectrometer

Thermo Scientific Q Exactive UHMR

Q Exactive specialising in analysis in the high mass range, such as proteins
Ultra-high mass range of up to 80000 m/z
Quadrupole isolation up to 25000 m/z for Selected Ion Monitoring (SIM), MS/MS and pseudo-MS3 experiments
Resolution up to 200000 (FWHM) at 400 m/z
In-source trapping for higher transmission and better desolvation
Advanced Quadrupole Technology (AQT) for superior precursor isolation
Advanced Active Beam Guide (AABG) for greater sensitivity and maximum robustness

In Stock

Description

Thermo Q Exactive UHMR Mass Spectrometer

Designed specifically for the analysis of macromolecules such as proteins, applications include but are not limited to: top-down proteomics, intact protein analysis and native mass spectrometry. This ultra high mass range mass spectrometer is able to analyse up to 80000 m/z, has precursor selection up to 25000 m/z, without compromising on sensitivity. In-source trapping in the injection flatapole region provides controllable desolvation and fragmentation, focusing of the ion cloud for improved transmission, and the ability to perform pseudo-MS. Advanced Quadrupole Technology (AQT) featuring a segmented Thermo Scientific™ HyperQuad™ mass filter provides increased ion transmission and superior isolation window shape. We can provide the necessary software, an LC system and/or forevacuum pump as required. Warranty options available, please get in touch!

Operation modes

Full MS with high-resolution, accurate-mass detection
SIM with high-resolution, accurate-mass detection
All Ion Fragmentation (AIF) using in-source CID, in-source trapping or HCD
MS/MS and pseudo-MS3 of isolated ions with high-resolution, accurate-mass detection

Exclusive technologies

In-source trapping
High-performance HCD cell for highest quality MS/MS and pseudo-MS3 data
Advanced Precursor Determination (APD)
Advanced signal processing

Performance characteristics

Resolution: 200000 at 400 m/z
Mass range: 350 to 80000 m/z
Precursor mass selection: Up to 25000 m/z
Scan rate: 12 Hz at resolution setting of 12500 at 400 m/z
Mass accuracy: Internal: <1 ppm RMS External: <3 ppm
Dynamic range: >5000:1
Analog inputs: One (1) analog input (0–1 V), One (1) analog (0–10 V)

Orbitrap mass analyser

Nitrogen-filled combo C-Trap and HCD collision cell with an applied axial field with improved fragment ion extraction and trapping capabilities
Highly efficient ion transfer to the Orbitrap mass analyser
Voltage ramp rate adjustment on the central Orbitrap electrode for enhanced transmission of high mass ions from the C-Trap into the Orbitrap analyzer
Orbitrap mass analyzer with 5 kV central electrode voltage
Low-noise image current preamplifier for high mass ions
16-bit signal digitalization